LOCAS – A Low Coverage Assembly Tool for Resequencing Projects
نویسندگان
چکیده
منابع مشابه
LOCAS – A Low Coverage Assembly Tool for Resequencing Projects
MOTIVATION Next Generation Sequencing (NGS) is a frequently applied approach to detect sequence variations between highly related genomes. Recent large-scale re-sequencing studies as the Human 1000 Genomes Project utilize NGS data of low coverage to afford sequencing of hundreds of individuals. Here, SNPs and micro-indels can be detected by applying an alignment-consensus approach. However, com...
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Within the last five years, a new generation of sequencing technologies has dramatically reduced cost and at the same time increased throughput of genome sequencing. For most application fields these technologies have proven to be good alternatives to the traditional Sanger sequencing although they generate shorter read sequences. For the study of sequence variations like SNPs, indels and longe...
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Research in the genomic sciences is confronted with the volume of sequencing and resequencing data increasing at a higher pace than that of data storage and communication resources, shifting a significant part of research budgets from the sequencing component of a project to the computational one. Hence, being able to efficiently store sequencing and resequencing data is a problem of paramount ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0023455